Webinars
Webinars are hosted by the ISBM Early Career Investigator Committee and are open to members and non-members of ISBM at all career stages. Priority is given to Early Career Investigators to introduce themselves and meet the speaker at the end of the webinar. Our goal is to support students and fellows that are interested in joining an active community of researchers focused on the quantitative imaging and analysis of skeletal tissues (histomorphometry, immunostaining, lineage tracing, live imaging, CT, tissue clearing, morphometrics, spatial transcriptomics, etc).
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- Previously recorded webinars can be found on our ISBM YouTube Channel
- Note: some webinars may not be shared based on the permission of the presenter
Dr. Eva Wölfel
University of Southern Denmark
Dr. Shatavisha Dasgupta
Broad Institute of MIT and Harvard
Dr. Joseph Wallace and this Bone Biology and Mechanics Laboratory (BBML) at IUPUI are committed to improving our understanding of how the body works through innovative preclinical and clinical research. The lab focuses on bone mechanics (ability to effectively bear loads) and mechanobiology (how cells respond to mechanical stimuli to maintain and/or increase bone mass) in the context of disease and treatment. We investigate bone from mechanical engineering and materials science perspectives by tying morphology and composition to mechanical function and fracture resistance at discrete length scales throughout bone’s rich tissue hierarchy. Our long-term goal is to use combinatorial treatments targeting deficiencies in bone mass/quantity and bone tissue quality in complex disease states that have musculoskeletal complications leading to fragility and fracture. Our current focus is on mechanical and pharmaceutical manipulations in diseases including diabetes and chronic kidney disease.
Careers take many twists and turns, but one thing remains consistent: a large part of your day is spent at work, so you’d better make it something you enjoy! During this webinar Dr. Lara Silverman will discuss some tips to sniff out a potential new employer, ways to reassess and remain impartial while you’re at a job, and approaches to making big changes in your career path. Also, we will discuss types of industry roles that exist for scientists, the role of ‘company culture’ in your day to day life, and how to find your ideal career in hopes of avoiding burn-out.
During this webinar Dr. Anjali Kusumbe will present a new and efficient pipeline for clearing and immunolabeling intact calcified tissues, allowing for superfast, single-cell resolution, and quantitative 3D imaging of skeletal elements and discovery of lymphatic vessels in bones. The application of this rapid imaging technique revealed unexpected lymphatic vascular networks in bones, challenging the conventional belief that bones lack lymphatic vessels. Using high-resolution light-sheet imaging and cell-specific mouse genetics, demonstrated the presence of lymphatic vessels in both mouse and human bones. Furthermore, this research uncovers that lymphatic vessel expand in response to genotoxic stress, driven by VEGF-C/VEGFR-3 signaling and stress-induced IL6. During lymph angiogenesis, the secretion of CXCL12 from proliferating lymphatic endothelial cells emerged as a crucial factor for hematopoietic and bone regeneration. Additionally, lymphatic vessel derived CXCL12 induced the expansion of mature Myh11+ CXCR4+ pericytes, which differentiate into bone cells and contribute to both bone and hematopoietic regeneration. The study suggests that targeting bone lymphatics could serve as a therapeutic strategy to stimulate hematopoietic and bone regeneration, particularly in the context of stress and injury, with implications for age-related impairment of bone regeneration.
