Dr. Joseph Wallace and this Bone Biology and Mechanics Laboratory (BBML) at IUPUI are committed to improving our understanding of how the body works through innovative preclinical and clinical research. The lab focuses on bone mechanics (ability to effectively bear loads) and mechanobiology (how cells respond to mechanical stimuli to maintain and/or increase bone mass) […]

Careers take many twists and turns, but one thing remains consistent: a large part of your day is spent at work, so you’d better make it something you enjoy! During this webinar Dr. Lara Silverman will discuss some tips to sniff out a potential new employer, ways to reassess and remain impartial while you’re at […]

During this webinar Dr. Anjali Kusumbe will present a new and efficient pipeline for clearing and immunolabeling intact calcified tissues, allowing for superfast, single-cell resolution, and quantitative 3D imaging of skeletal elements and discovery of lymphatic vessels in bones. The application of this rapid imaging technique revealed unexpected lymphatic vascular networks in bones, challenging the […]

During this webinar Dr. Morten Frost will discuss incretin hormone-based therapies of common conditions including type 2 diabetes and obesity are rapidly emerging. While preclinical studies indicate that GLP-1 advances bone formation and GIP decreases bone resorption, clinical studies based on early GLP-1 receptor agonists show neutral effects on bone. However, more recent GLP-1 and […]

During this webinar Dr. Thomas Andersen will discuss how thousands of bone remodeling units (BRUs) constantly renew our bones throughout our lives. These units are also known as basic multicellular units (BMUs) and involves a highly coordinated bone resorption and formation. This webinar will cover the recently revised phases of the BMUs and the key […]

During this webinar Dr. Graeme Campbell will discuss how computed tomography (CT) is considered the “workhorse” of diagnostic imaging in almost all clinical subdisciplines. It is indispensable in terms of its availability, standardization, examination speed and options for integration into complex clinical workflows. In the musculoskeletal (MSK) domain, CT provides high-resolution images of bony structures, […]

During this webinar Dr. Sarah Dallas will discuss using live cell imaging in combination with transgenic mice expressing GFP-tagged collagen and fluorescent reporters to visualize bone cell lineages, our work has advanced fundamental understanding of bone extracellular matrix assembly and resorption dynamics. Live cell imaging has revealed the dynamic mechanisms of osteocyte embedding in collagen […]