During this webinar Dr. Michelle McDonald will discuss using a novel intravital imaging technique to visualise tumour cell fate, bone cell dynamics and tumour-bone cell interactions we have advanced our fundamental understanding of tumour cell dormancy and osteoclast biology, and uncovered mechanisms behind clinical responses to anti-resorptive therapies. Through targeting this novel cell biology, we are defining strategies to prevent bone loss in patients who are withdrawn from anti-RANKL therapy. We are also investigating new approaches to prevent bone metastatic tumours indirectly through targeting the bone microenvironment.

During this webinar, Dr. Ralph Müller will delve into the intricate field of multiscale bone biomechanics and imaging. From milliseconds to years and nanometers to centimeters, bone biomechanics require integrating information across various scales. Explore Dr. Müller’s research, which combines mechanics and microstructural imaging, employing computer simulations and experimental validation. Discover image-guided techniques that provide 4D visualization of fracture progression at the nanometer scale. Gain insights into the fascinating world of bone mechanobiology, where complex interactions between cells and their microenvironments drive the process of bone remodeling. Understand how mechanical cues influence cellular responses and uncover the latest advances in studying bone mechanobiology across multiple scales. Join us to unravel the mysteries of bone biomechanics and imaging!

During this webinar, Dr. Leigh Gabel will discuss the importance of movement (physical activity and exercise) during childhood and adolescence for developing a healthy skeleton and how different imaging modalities (e.g., DXA, pQCT, HR-pQCT) help us understand the intricacies of bone accrual. Dr. Gabel will also discuss how prolonged unloading (i.e., long-duration spaceflight) impacts bone microarchitecture and strength during adulthood.